Leibniz Research Alliance
Healthy Ageing

© FLI / Foto: Anna Schroll

Joint Publications

Naked mole-rat project (IZW and FLI)

Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G. (2015): Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma. PLoS One 10(6), e0130470.

Henning Y, Vole C, Begall S, Bens M, Broecker-Preuss M, Sahm A, Szafranski K, Burda H, Dammann P. (2014): Unusual ratio between free thyroxine and free triiodothyronine in a long-lived mole-rat species with bimodal ageing. PLoS One 19;9(11), e113698.

Roellig K, Drews B, Goeritz F, Hildebrandt TB. (2011): The long gestation of the small naked mole-rat (Heterocephalus glaber RÜPPELL, 1842) studied with ultrasound biomicroscopy and 3D-ultrasonography. PLoS One 6, e17744.

Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM. (2011): RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. PLoS One 6, e26729.

Dziegelewska M, Holtze S, Vole C, Wacher U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt T, Platzer M (2016): Low sulfide levels and high degree of cystathionine ß-synthase (CBS) activiation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Rewdox Biol. 8:192-198. dio: 10.1016/j.redox.2016.01.008.

Bens M, Sahm A, Groth M, Jahn N, Morhart M, Holtze S, Hildebrandt TB, Platzer M, Szafranski K (2016): FRAMA: from RNA-seq data tzo annotated mRNA assemblies. BMC Genomics 17(1):54. doi: 10.1186/s12864-015-2349-8.

FLI and DIfE

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran 1, Dommaschk 3, Schmeisser 3, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M (2015): Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nat Commun. 6:10043. doi: 10.1038/ncomms10043.

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M (2014): D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Nat Commun. 2014 Apr 8;5:3563. doi: 10.1038/ncomms4563.

DIfE and DDZ

Lubura M, Hesse D, Kraemer M, Hallahan N, Schupp M, von Löffelholz C, Kriebel J, Rudovich N, Pfeiffer A, John C, Scheja L, Heeren J, Koliaki C, Roden M, Schürmann A. (2015): Diabetes prevalence in NZO females depends on estrogen action on liver fat content. Am J Physiol Endocrinol Metab. 309(12):E968-80. doi: 10.1152/ajpendo.00338.2015.

Hattersley JG1, Pfeiffer AF, Roden M, Petzke KJ, Hoffmann D, Rudovich NN, Randeva HS, Vatish M, Osterhoff M, Goegebakan Ö, Hornemann S, Nowotny P, Machann J, Hierholzer J, von Loeffelholz C, Möhlig M, Arafat AM, Weickert MO (2014): Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content. J Clin Endocrinol Metab. 99(12):E2599-609. doi: 10.1210/jc.2014-2302.

Nowotny B, Zahiragic L, Bierwagen A, Kabisch S, Groener JB, Nowotny PJ, Fleitmann AK, Firouzi P, Herder C, Pacini G, Erlund I, Landberg R, Haering HU, Pfeiffer AF, Nawroth PP, Roden M (2016): Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial. Diabetologia.  [Epub ahead of print]


Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR (2014): Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. PLoS One. 9(7):e102425. doi: 10.1371/journal.pone.0102425.


Scharf A, Gührs KH, von Mikecz A ( 2016): Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans.Nanotoxicology. 10(4):426-35. doi: 10.3109/17435390.2015.1073399.

Zoch A, Mayerl S, Schulz A, Greither T, Frappart L, Rübsam J, Heuer H, Giovannini M, Morrison H (2015): Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation. PLoS One. 2015 Aug 10;10(8):e0129151. doi: 10.1371/journal.pone.0129151.

Li H, Moll J, Winkler A, Frappart L, Brunet S, Hamann J, Kroll T, Verlhac MH, Heuer H, Herrlich P, Ploubidou A (2015): RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biol Open. 4(4):562-71. doi: 10.1242/bio.201410892.

Mayerl S, Liebsch C, Visser TJ, Heuer H (2015): Absence of TRH receptor 1 in male mice affects gastric ghrelin production. Endocrinology. 156(2):755-67. doi: 10.1210/en.2014-1395.

Kersseboom S, Horn S, Visser WE, Chen J, Friesema EC, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ (2014): In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. Mol Endocrinol. 28(12):1961-70. doi: 10.1210/me.2014-1135.

Müller J, Heuer H (2014): Expression pattern of thyroid hormone transporters in the postnatal mouse brain. Front Endocrinol (Lausanne). 5:92. doi: 10.3389/fendo.2014.00092.

Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H. Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Endocrinology. 155(1):315-25. doi: 10.1210/en.2013-1800.


Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ (2015): KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.Nat Commun. 6:6254. doi: 10.1038/ncomms7254.

Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Meineke BM, Freund C, Budinger E, Stork O (2014): The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. J Neurosci. 34(15):5342-54. doi: 10.1523/JNEUROSCI.2728-13.2014.


Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A. (2014): Role of Blimp-1 in programing Th effector cells into IL-10 producers.J Exp Med. 211(9):1807-19. doi: 10.1084/jem.20131548.


Winter Y, Pieper L, Klotsche J3, Riedel O, Wittchen HU. ( 2016): Obesity and Abdominal Fat Markers in Patients with a History of Stroke and Transient Ischemic Attacks. J Stroke Cerebrovasc Dis. pii: S1052-3057(15)00694-1. doi: 10.1016/j.jstrokecerebrovasdis.2015.12.026. [Epub ahead of print].

Ritz T, Wittchen HU, Klotsche J, Mühlig S, Riedel O, sap-NEEDs study group *. (2016): Asthma Trigger Reports Are Associated with Low Quality of Life, Exacerbations, and Emergency Treatments. Ann Am Thorac Soc. 13(2):204-11. doi: 10.1513/AnnalsATS.201506-390OC.

Riedel O, Klotsche J, Wittchen HU; GEPAD study group (2014): Motor impairment, depression, dementia: which forms the impression of disease severity in Parkinson's disease? Parkinsonism Relat Disord. 20(12):1365-70. doi: 10.1016/j.parkreldis.2014.09.025.


Teichert T, Hellwig A, Peßler A, Hellwig M, Vossoughi M, Sugiri D, Vierkötter A, Schulte T, Freund J, Roden M, Hoffmann B, Schikowski T, Luckhaus C, Krämer U, Henle T, Herder C (2015): Association between Advanced Glycation End Products and Impaired Fasting Glucose: Results from the SALIA Study. PLoS One. 10(5):e0128293. doi: 10.1371/journal.pone.0128293. eCollection 2015.

Spatial Science (ILS and IÖR)

Banse J, Berndgen-Kaiser A, Deilamnn C, Fox-Kämper R, Möbius M (2015): Wohnsituation und Wohnwünsche älterer Menschen in ost- und westdeutschen Städten. Stuttgart, Fraunhofer IRB Verlag.



Publications of the institutes

Here you can find the most relevant publications of the member institutes concerning ageing research. The list is sorted by the sections of the Leibniz Association.

Section A: Humanities and Educational Research

Section B: Economics, Social Sciences and Spatial Research

Section C: Life Sciences

Section D: Mathematics, Natural Sciences, Engineering

Section A: Humanities and Educational Research

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Section B: Economics, Social Sciences and Spatial Research

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Section C: Life Sciences

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Section D: Mathematics, Natural Sciences and Engineering

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