The continuous increase in life expectancy and age-related diseases represents an ethical and economic challenge to human society. The project aims to identify molecular networks underlying the exceptional healthy longevity (healthspan) of naked mole-rats. Defying the common trade-off between fecundity and lifespan, reproductive individuals of eusocial species have developed mechanisms resisting ageing. Mole-rats provide a unique opportunity to study the transition of shorter-lived non-breeders into longer-lived breeders. Comparative transcriptomics with free-ranging mole-rats, guinea pigs and mice shall identify underlying genes, subsequently validated in cell culture. Obtained results are aimed at translation into sustained health in an ageing human society.
Period: 1 January 2012 - 31 December 2014
Contact: PD Dr. Matthias Platzer
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Phone: ++49 (0)3641-65 62 41
Sahm A, Bens M, Platzer M, Szafranski K (2017): PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes. Nucleic Acids Res gkx179.DOI:https://doi.org/10.1093/nar/gkx179
Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, Konig B, Birkenmeier G (2016): Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat. Gutt Pathog 8: 25. doi: 10.1186/s13099-016-0107-3.
Dziegelewska M, Holtze S, Vole C, Wachter U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt T, Platzer M (2016): Low sulfide levels and a high degree of cystathionine beta-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Redox Biol 8: 192-198.
Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G. (2015): Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma. PLoS One 10(6), e0130470.
Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM. (2011): RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. PLoS One 6, e26729.