Leibniz Research Alliance
Healthy Ageing

© FLI, Stefan Guenther

Naked mole-rate - Exploring natural ways to an exceptional long healthspan

The continuous increase in life expectancy and age-related diseases represents an ethical and economic challenge to human society. The project aims to identify molecular networks underlying the exceptional healthy longevity (healthspan) of naked mole-rats. Defying the common trade-off between fecundity and lifespan, reproductive individuals of eusocial species have developed mechanisms resisting ageing. Mole-rats provide a unique opportunity to study the transition of shorter-lived non-breeders into longer-lived breeders. Comparative transcriptomics with free-ranging mole-rats, guinea pigs and mice shall identify underlying genes, subsequently validated in cell culture. Obtained results are aimed at translation into sustained health in an ageing human society.

Website of the project

Period: 1 January 2012 - 31 December 2014

Contact: PD Dr. Matthias Platzer
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Phone: ++49 (0)3641-65 62 41
matthias.platzer(at)leibniz-fli.de


Publications:

Sahm A, Bens M, Platzer M, Szafranski K (2017): PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes. Nucleic Acids Res gkx179.DOI:https://doi.org/10.1093/nar/gkx179

Bens M, Sahm A, Groth M, Jahn N, Morhart M, Holtze S, Hildebrandt TB, Platzer M, Szafranski K (2016): FRAMA: from RNA-seq data to annotated mRNA assemblies. BMC Genomics 17: 54.

Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, Konig B, Birkenmeier G (2016): Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat. Gutt Pathog 8: 25. doi: 10.1186/s13099-016-0107-3.

Dziegelewska M, Holtze S, Vole C, Wachter U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt T, Platzer M (2016): Low sulfide levels and a high degree of cystathionine beta-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Redox Biol 8: 192-198.

Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G. (2015): Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma. PLoS One 10(6), e0130470.

Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM. (2011): RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. PLoS One 6, e26729.

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