Leibniz Research Alliance
Healthy Ageing

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ImmuneAging - Aging of the immune system and its consequences for organsimal ageing

Decreases in organ function, impairments in stress resistance, and increases in the incidence of aging-associated disease represent major problems that limit the quality of life during aging. There is experimental and clinical evidence that age-related alterations in immune functions contribute to the evolution of organ pathologies and diseases during organismal aging. Aging of the immune system - also known as immunosenescence - is characterized by decreasing immune protection against pathogens, accompanied by increases in chronic, low grade inflammation and a growing incidence of several autoimmune diseases. Projects focus (i) on cell-intrinsic and cell-extrinsic mechanisms that promote alterations in the composition and function of immune cells during aging, (ii) mechanisms that promote inflammation during aging and its consequences on aging of the inflamed tissue and the aging organism and (iii) on the impact of an aging immune system on the development and progression of specific aging-associated diseases.

Period: 1 Januar 2017 - 31 December 2018

Prof. Dr. K. Lenhard Rudolph
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Dr. Winfried Göttsch
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Phone: ++49 (0)3641 / 65 63 15

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