Leibniz Research Alliance
Healthy Ageing

© FLI / Foto: Anna Schroll

Adipokines and myokines - Common language of muscle and fat?

The aim of this project is to clarify the role of adipokines and myokines in fat disposition in skeletal muscle and to study the crosstalk  between adipocytes and myocytes. To this end, we will establish a sustainable network for muscle research in humans, animal models and farm animals. This will be accomplished by the exchange of methods, models, data and expertise of all partners. Although the partners ultimately have different goals (opti­mization of meat quality in farm animals and identification of novel ther­apeutic targets in humans) understanding the common basic principles is essential to accomplish these goals, making the project beneficial for all partners.

Website of the project

Period: 1 March 2013 - 29 February 2016

Contact: Prof. Dr. Steffen Maak
Leibniz Institute for Farm Animal Biology (FBN)
Phone: ++49 (0)38208-68 850


Albrecht E, Norheim F, Thiede B, Holen T, Ohashi T, Schering L, Lee S, Brenmoehl J, Thomas S, Drevon CA, Erickson HP, Maak S (2015): Irisin – a myth rather than an exercise-inducible myokine. Sci Rep 5 (2015) 8889. doi: 10.1038/srep08889.

Bohm A, Hoffmann C, Irmler M, Schneeweiss P, Schnauder G, Sailer C, Schmid V, Hudemann J, Machann J, Schick F, Beckers J, Hrabe dA, Staiger H, Fritsche A, Stefan N, Niess AM, Haring HU, Weigert C (2016): TGFbeta contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle. Diabetes 65 (2016) 2849-2861. doi: 10.2337/db15-1723.

Brenmoehl J, Albrecht E, Komolka K, Schering L, Langhammer M, Hoeflich A, Maak S (2014): Irisin is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise. Int J Biol Sci 10 (2014) 338-349. doi: 10.7150/ijbs.

Eckardt K, Görgens SW, Raschke S, Eckel J (2014): Myokines in insulin resistance and type 2 diabetes. Diabetologia 57 (2014) 1087-1099. doi: 10.1007/s00125-014-3224-x.

Elsen M, Raschke S, Eckel J (2014): Browning of white fat: does irisin play a role in humans? J Endocrinol 222 (2014) R25-38. doi: 10.1530/JOE-14-0189.

Görgens SW, Eckardt K, Jensen J, Drevon CA, Eckel J (2015): Exercise and Regulation of Adipokine and Myokine Production. Prog Mol Biol Transl Sci 135 (2015) 313-336. doi: 10.1016/bs.pmbts.2015.07.002.

Hansen JS, Clemmesen JO, Secher NH, Hoene M, Drescher A, Weigert C, Pedersen BK, Plomgaard P (2015): Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans. Mol Metab 4 (2015) 551-560. doi: 10.1016/j.molmet.2015.06.001.

Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W, Muller S, Hanisch FG, Franz T, Li X, Dicken HD, Eckardt K, Beckers J, de Angelis MH, Weigert C, Haring HU, Al Hasani H, Ouwens DM, Eckel J, Kotzka J, Lehr S (2014): Secretome profiling of primary human skeletal muscle cells. Biochimica et Biophysica Acta 1844 (2014) 1011-1017. doi: 10.1016/j.bbapap.2013.08.004.

Hoene M, Li J, Haring HU, Weigert C, Xu G, Lehmann R (2014): The lipid profile of brown adipose tissue is sex-specific in mice. Biochimica et Biophysica Acta 1842 (2014) 1563-1570. doi: 10.1016/j.bbalip.2014.08.003.

Hoene M, Li J, Li Y, Runge H, Zhao X, Haring HU, Lehmann R, Xu G, Weigert C (2016): Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice. Sci Rep 6 (2016) 22218. doi: 10.1038/srep22218.

Hoffmann C, Weigert C (2017): Skeletal Muscle as an endocrine organ: The role of myokines in exercise adaptations. Cold Spring Harbor Perspectives in Medicine 2017(in press)

Kanzleiter T, Rath M, Görgens SW, Jensen J, Tangen DS, Kolnes AJ, Kolnes KJ, Lee S, Eckel J, Schürmann A, Eckardt K (2014): The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochem Biophys Res Commun 450 (2014) 1089-1094. doi: 10.1016/j.bbrc.2014.06.123.

Komolka K, Albrecht E, Schering L, Brenmoehl J, Hoeflich A, Maak S (2014): Locus characterization and gene expression of bovine FNDC5: Is the myokine irisin relevant in cattle? PLoS One 9 (2014) e88060. doi: 10.1371/journal.pone.0088060.

Ost M, Keipert S, van Schothorst EM, Donner V, van der Stelt I, Kipp AP, Petzke KJ, Jove M, Pamplona R, Portero-Otin M, Keijer J, Klaus S (2015): Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux. FASEB J. 29 (2015) 1314-1328. doi: 10.1096/fj.14-261503.

Ost M, Coleman V, Voigt A, van Schothorst EM, Keipert S, van der Stelt I, Ringel S, Graja A, Ambrosi T, Engst W, Kipp AP, Jastroch M, Schulz TJ, Keijer J, Klaus S (2016a): Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. Mol Metabol. 5 (2016a) 79-90. doi:  10.1016/j.molmet.2015.11.002

Ost M, Coleman V, Kasch J, Klaus S (2016b): Regulation of myokine expression: Role of exercise and cellular stress. Free Radic Biol Med 98 (2016b) 78-89. doi: 10.1016/j.freeradbiomed.2016.02.018.

Ost M, Keipert S, Klaus S (2017): Targeted mitochondrial uncoupling beyond UCP1 – the fine line between death and metabolic health. Biochimie 134 (2017) 77-85. doi: 10.1016/j.biochi.2016.11.013.

Schering L, Hoene M, Kanzleitner T, Jähnert M, Wimmers K, Klaus S, Eckel J, Weigert C, Schürmann A, Maak S, Jonas W, Sell H (2015): Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles. Arch Physiol Biochem 121 (2015) 194-205. doi: 10.3109/13813455.2015.1092044.

Schering L, Albrecht E, Komolka K, Kühn C, Maak S (2017): Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause 1 of higher intramuscular fat content in cattle. Int J Biol Sci (2017 in press); doi:10.7150/ijbs.18775

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