Type 2 diabetes mellitus is one of the most important diseases in ageing populations and as such an increasing public health problem, causing high individual and societal burden. The main challenge is the prevention of its comorbidities. There is a great variability in the course of the disease, with patients who have long time diabetes without any disabilities up to those with early severe diabetes-associated complications. This variability is poorly understood. Individual biological factors, psychological aspects, life style, socioeconomic conditions, or environmental factors may play a role, probably in complex interaction. Aim of this focus group is to analyze predictors for the individual course of type 2 diabetes, and to develop a comprehensive bio-psycho-social-environmental model which can be used to offer individualized health care. Several infrastructure resources within Leibniz are exploited including molecular tools, model organisms, biobanks, and large cohort studies.